Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents

• Váldodahkkit: Dhulfiqar Ali Abed (Dahkki), Melanie Goldstein (Dahkki), Haifa Albanyan (Dahkki), Huijuan Jin (Dahkki), Longqin Hu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2015-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The Keap1-Nrf2-ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1-Nrf2 protein-protein interaction (PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes...