Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents

• Main Authors: Dhulfiqar Ali Abed (Author), Melanie Goldstein (Author), Haifa Albanyan (Author), Huijuan Jin (Author), Longqin Hu (Author)
• 格式: 圖書
• 出版: Elsevier, 2015-07-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The Keap1-Nrf2-ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1-Nrf2 protein-protein interaction (PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes...