Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage

• Main Authors: Joyce E. Gutiérrez (Author), Esteban Fernandez-Moreira (Author), Miguel A. Rodríguez (Author), Michael R. Mijares (Author), Juan Bautista De Sanctis (Author), Soňa Gurská (Author), Petr Džubák (Author), Marián Hajdůch (Author), Julia Bruno-Colmenarez (Author), Luis Rojas (Author), Denis Deffieux (Author), Laurent Pouységu (Author), Stéphane Quideau (Author), Jaime Charris (Author), Hegira Ramírez (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 78 synthetic 7-chloro-(4-thioalkylquinoline) derivatives were investigated for cytotoxic activity against eight human cancer as well as 4 non-tumor cell lines. The results showed, with some exceptions, that sulfanyl <b>5</b>-<b>40</b> and sulfinyl <b>41</...