Alzheimer's Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model

• Autors principals: Yousif Aldabbagh (Autor), Anam Islam (Autor), Weicong Zhang (Autor), Paul Whiting (Autor), Afia B. Ali (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Cognitive decline is a major symptom in Alzheimer's disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered in APP knock-in mouse model of AD and whether this is correlate...