Defining Exposure Predictors of Meropenem That Are Associated with Improved Survival for Severe Bacterial Infection: A Preclinical PK/PD Study in Sepsis Rat Model

• Główni autorzy: Yan Wang (Autor), Lanyu Liu (Autor), Qiping Wu (Autor), Qiufen Yin (Autor), Feifan Xie (Autor)
• Format: Książka
• Wydane: MDPI AG, 2022-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

<b>Background</b>: The pharmacokinetic/pharmacodynamic (PK/PD) index of carbapenems that best correlates with in vivo antimicrobial activity is percent time of dosing interval in which free drug concentration remains above MIC (%<i>f</i>T > MIC), while the magnitudes of th...