Defining Exposure Predictors of Meropenem That Are Associated with Improved Survival for Severe Bacterial Infection: A Preclinical PK/PD Study in Sepsis Rat Model

• मुख्य लेखकों: Yan Wang (लेखक), Lanyu Liu (लेखक), Qiping Wu (लेखक), Qiufen Yin (लेखक), Feifan Xie (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

<b>Background</b>: The pharmacokinetic/pharmacodynamic (PK/PD) index of carbapenems that best correlates with in vivo antimicrobial activity is percent time of dosing interval in which free drug concentration remains above MIC (%<i>f</i>T > MIC), while the magnitudes of th...