Differential Coupling of Human Endothelin Type A Receptor to Gq/11 and G12 Proteins: the Functional Significance of Receptor Expression Level in Generating Multiple Receptor Signaling

• Autores principales: Takahiro Horinouchi (Autor), Hiroshi Asano (Autor), Tunaki Higa (Autor), Arata Nishimoto (Autor), Tadashi Nishiya (Autor), Ikunobu Muramatsu (Autor), Soichi Miwa (Autor)
• Formato: Libro
• Publicado: Elsevier, 2009-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

This study examines the influence of receptor expression level on signaling pathways activated via endothelin type A receptor (ETAR) expressed in Chinese hamster ovary cells at 32,100 (ETAR-high-CHO) and 893 (ETAR-low-CHO) fmol·mg protein−1. Endothelin-1 (ET-1) elicited a sustained increase in intra...