Differential Coupling of Human Endothelin Type A Receptor to Gq/11 and G12 Proteins: the Functional Significance of Receptor Expression Level in Generating Multiple Receptor Signaling

• Main Authors: Takahiro Horinouchi (Author), Hiroshi Asano (Author), Tunaki Higa (Author), Arata Nishimoto (Author), Tadashi Nishiya (Author), Ikunobu Muramatsu (Author), Soichi Miwa (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study examines the influence of receptor expression level on signaling pathways activated via endothelin type A receptor (ETAR) expressed in Chinese hamster ovary cells at 32,100 (ETAR-high-CHO) and 893 (ETAR-low-CHO) fmol·mg protein−1. Endothelin-1 (ET-1) elicited a sustained increase in intra...