Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment

• Main Authors: Shravan Babu Girada (Author), Ramya S. Kuna (Author), Shilpak Bele (Author), Zhimeng Zhu (Author), N.R. Chakravarthi (Author), Richard D. DiMarchi (Author), Prasenjit Mitra (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and recycling back to the plasma membrane, or it...