Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment

• Auteurs principaux: Shravan Babu Girada (Auteur), Ramya S. Kuna (Auteur), Shilpak Bele (Auteur), Zhimeng Zhu (Auteur), N.R. Chakravarthi (Auteur), Richard D. DiMarchi (Auteur), Prasenjit Mitra (Auteur)
• Format: Livre
• Publié: Elsevier, 2017-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Objective: Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and recycling back to the plasma membrane, or it...