Deciphering the decisive factors driving fate bifurcations in somatic cell reprogramming

• Main Authors: Chunshen Long (Author), Hanshuang Li (Author), Pengfei Liang (Author), Lemuge Chao (Author), Yan Hong (Author), Junping Zhang (Author), Qilemuge Xi (Author), Yongchun Zuo (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Single-cell studies have demonstrated that somatic cell reprogramming is a continuous process of cell fates transition. Only partial reprogramming intermediates can overcome the molecular bottlenecks to acquire pluripotency. To decipher the underlying decisive factors driving cell fate, we identifie...