Targeting murine alveolar macrophages by the intratracheal administration of locked nucleic acid containing antisense oligonucleotides

• Main Authors: Yasunori Uemura (Author), Katsuya Kobayashi (Author)
• 格式: 圖書
• 出版: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The pulmonary delivery of locked nucleic acid containing antisense oligonucleotides (LNA-ASOs) is expected to be a novel therapeutic approach for lung diseases. However, there are two concerns to be considered: immune responses, as the lung has a distinct immune mechanism to protect it from inhaled...