MicroRNA-212-5p, an anti-proliferative miRNA, attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents

• Main Authors: Tianji Chen (Author), Miranda R. Sun (Author), Qiyuan Zhou (Author), Alyssa M. Guzman (Author), Ramaswamy Ramchandran (Author), Jiwang Chen (Author), Dustin R. Fraidenburg (Author), Balaji Ganesh (Author), Mark Maienschein-Cline (Author), Karl Obrietan (Author), J. Usha Raj (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNAs (miRNA, miR-) play important roles in disease development. In this study, we identified an anti-proliferative miRNA, miR-212-5p, that is induced in pulmonary artery smooth muscle cells (PASMCs) and lungs of pulmonary hypertension (PH) patients and rodents with experimental PH. We found tha...