A systematic efficacy analysis of tuberculosis treatment with BPaL‐containing regimens using a multiscale modeling approach

• Main Authors: Maral Budak (Author), Laura E. Via (Author), Danielle M. Weiner (Author), Clifton E. Barry III (Author), Pariksheet Nanda (Author), Gabrielle Michael (Author), Khisimuzi Mdluli (Author), Denise Kirschner (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tuberculosis (TB) is a life‐threatening infectious disease. The standard treatment is up to 90% effective; however, it requires the administration of four antibiotics (isoniazid, rifampicin, pyrazinamide, and ethambutol [HRZE]) over long time periods. This harsh treatment process causes adh...