Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles

• Glavni autori: Daniel W. Binzel (Autor), Songchuan Guo (Autor), Hongran Yin (Autor), Tae Jin Lee (Autor), Shujun Liu (Autor), Dan Shu (Autor), Peixuan Guo (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2021-09-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Small interfering RNA (siRNA) for silencing genes and treating disease has been a dream since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA approval of four siRNA-based drugs, the potential of RNA therapeutics to become the third milestone in pharmaceutical drug d...