Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles

• Main Authors: Daniel W. Binzel (Author), Songchuan Guo (Author), Hongran Yin (Author), Tae Jin Lee (Author), Shujun Liu (Author), Dan Shu (Author), Peixuan Guo (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small interfering RNA (siRNA) for silencing genes and treating disease has been a dream since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA approval of four siRNA-based drugs, the potential of RNA therapeutics to become the third milestone in pharmaceutical drug d...