Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV

• Main Authors: Shih-Han Ko (Author), Yi-Jen Liau (Author), Ya-Hui Chi (Author), Mei-Ju Lai (Author), Yu-Ping Chiang (Author), Chun-Yi Lu (Author), Luan-Yin Chang (Author), Woan-Yuh Tarn (Author), Li-Min Huang (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The molecular chaperon MRJ (DNAJB6) exhibits two splice isoforms that have different roles in human viral infection, but the regulatory mechanism of MRJ isoform expression is yet unclear. In this study, we show that reduction of the polyadenylation factor CstF64 was correlated with the increase of t...