Dual Carbonic Anhydrase IX/XII Inhibitors and Carbon Monoxide Releasing Molecules Modulate LPS-Mediated Inflammation in Mouse Macrophages

• Main Authors: Emanuela Berrino (Author), Simone Carradori (Author), Andrea Angeli (Author), Fabrizio Carta (Author), Claudiu T. Supuran (Author), Paolo Guglielmi (Author), Cecilia Coletti (Author), Roberto Paciotti (Author), Helmut Schweikl (Author), Francesca Maestrelli (Author), Elisabetta Cerbai (Author), Marialucia Gallorini (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Low concentrations of carbon monoxide (CO) were reported to exhibit anti-inflammatory effects when administered in cells by suitable chemotypes such as CO releasing molecules (CO-RMs). In addition, the pH-modulating abilities of specific carbonic anhydrase isoforms played a crucial role in different...