New NADPH Oxidase 2 Inhibitors Display Potent Activity against Oxidative Stress by Targeting p22^phox-p47^phox Interactions

• Autores principales: Adriana V. Treuer (Autor), Mario Faúndez (Autor), Roberto Ebensperger (Autor), Erwin Hovelmeyer (Autor), Ariela Vergara-Jaque (Autor), Yunier Perera-Sardiña (Autor), Margarita Gutierrez (Autor), Roberto Fuentealba (Autor), Daniel R. González (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-07-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

NADPH oxidase (NOX2) is responsible for reactive oxygen species (ROS) production in neutrophils and has been recognized as a key mediator in inflammatory and cardiovascular pathologies. Nevertheless, there is a lack of specific NOX2 pharmacological inhibitors. In medicinal chemistry, heterocyclic co...