New NADPH Oxidase 2 Inhibitors Display Potent Activity against Oxidative Stress by Targeting p22^phox-p47^phox Interactions

• Egile Nagusiak: Adriana V. Treuer (Egilea), Mario Faúndez (Egilea), Roberto Ebensperger (Egilea), Erwin Hovelmeyer (Egilea), Ariela Vergara-Jaque (Egilea), Yunier Perera-Sardiña (Egilea), Margarita Gutierrez (Egilea), Roberto Fuentealba (Egilea), Daniel R. González (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

NADPH oxidase (NOX2) is responsible for reactive oxygen species (ROS) production in neutrophils and has been recognized as a key mediator in inflammatory and cardiovascular pathologies. Nevertheless, there is a lack of specific NOX2 pharmacological inhibitors. In medicinal chemistry, heterocyclic co...