New NADPH Oxidase 2 Inhibitors Display Potent Activity against Oxidative Stress by Targeting p22^phox-p47^phox Interactions

• Main Authors: Adriana V. Treuer (Author), Mario Faúndez (Author), Roberto Ebensperger (Author), Erwin Hovelmeyer (Author), Ariela Vergara-Jaque (Author), Yunier Perera-Sardiña (Author), Margarita Gutierrez (Author), Roberto Fuentealba (Author), Daniel R. González (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NADPH oxidase (NOX2) is responsible for reactive oxygen species (ROS) production in neutrophils and has been recognized as a key mediator in inflammatory and cardiovascular pathologies. Nevertheless, there is a lack of specific NOX2 pharmacological inhibitors. In medicinal chemistry, heterocyclic co...