New NADPH Oxidase 2 Inhibitors Display Potent Activity against Oxidative Stress by Targeting p22^phox-p47^phox Interactions

• Päätekijät: Adriana V. Treuer (Tekijä), Mario Faúndez (Tekijä), Roberto Ebensperger (Tekijä), Erwin Hovelmeyer (Tekijä), Ariela Vergara-Jaque (Tekijä), Yunier Perera-Sardiña (Tekijä), Margarita Gutierrez (Tekijä), Roberto Fuentealba (Tekijä), Daniel R. González (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2023-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

NADPH oxidase (NOX2) is responsible for reactive oxygen species (ROS) production in neutrophils and has been recognized as a key mediator in inflammatory and cardiovascular pathologies. Nevertheless, there is a lack of specific NOX2 pharmacological inhibitors. In medicinal chemistry, heterocyclic co...