Sufficient Cav-1 levels in the endothelium are critical for the maintenance of the neurovascular unit in the retina

• Main Authors: Yixin Wang (Author), Mahmoud Halawa (Author), Anupriya Chatterjee (Author), Rachana Eshwaran (Author), Yi Qiu (Author), Yohanes Cakrapradipta Wibowo (Author), Jianyuan Pan (Author), Thomas Wieland (Author), Yuxi Feng (Author)
• Format: Book
• Published: BMC, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Caveolin-1 (Cav-1) is a pivotal protein in the plasma membrane. Studies on homozygous Cav-1 deficient mice revealed that Cav-1 is essential for endothelial function and angiogenesis in the retina. However, whether a reduction in Cav-1 content hampers the neurovascular unit (NVU)...