Sufficient Cav-1 levels in the endothelium are critical for the maintenance of the neurovascular unit in the retina

• Hlavní autoři: Yixin Wang (Autor), Mahmoud Halawa (Autor), Anupriya Chatterjee (Autor), Rachana Eshwaran (Autor), Yi Qiu (Autor), Yohanes Cakrapradipta Wibowo (Autor), Jianyuan Pan (Autor), Thomas Wieland (Autor), Yuxi Feng (Autor)
• Médium: Kniha
• Vydáno: BMC, 2023-11-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Abstract Background Caveolin-1 (Cav-1) is a pivotal protein in the plasma membrane. Studies on homozygous Cav-1 deficient mice revealed that Cav-1 is essential for endothelial function and angiogenesis in the retina. However, whether a reduction in Cav-1 content hampers the neurovascular unit (NVU)...