Cdk5 knocking out mediated by CRISPR-Cas9 genome editing for PD-L1 attenuation and enhanced antitumor immunity

• Main Authors: Huan Deng (Author), Songwei Tan (Author), Xueqin Gao (Author), Chenming Zou (Author), Chenfeng Xu (Author), Kun Tu (Author), Qingle Song (Author), Fengjuan Fan (Author), Wei Huang (Author), Zhiping Zhang (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Blocking the programmed death-ligand 1 (PD-L1) on tumor cells with monoclonal antibody therapy has emerged as powerful weapon in cancer immunotherapy. However, only a minority of patients presented immune responses in clinical trials. To develop an alternative treatment method based on immune checkp...