An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

• मुख्य लेखकों: Blandine De La Gastine (लेखक), Soizic Percevault (लेखक), Laurent Varin (लेखक), Nicolas Richard (लेखक), Fabienne Fobe (लेखक), Benoît Plaud (लेखक), Georges Daccache (लेखक), Vincent Compere (लेखक), Jean-Jacques Parienti (लेखक), Antoine Coquerel (लेखक), Magalie Loilier (लेखक), Nathalie Bleyzac (लेखक), Laurent Bourguignon (लेखक), Sylvain Goutelle (लेखक), Véronique Lelong-Boulouard (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Cytochrome P450 2D6 (<i>CYP2D6</i>) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for <i>CYP2D6</i> phenotyping. The objective of the CY...