An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

• Main Authors: Blandine De La Gastine (Author), Soizic Percevault (Author), Laurent Varin (Author), Nicolas Richard (Author), Fabienne Fobe (Author), Benoît Plaud (Author), Georges Daccache (Author), Vincent Compere (Author), Jean-Jacques Parienti (Author), Antoine Coquerel (Author), Magalie Loilier (Author), Nathalie Bleyzac (Author), Laurent Bourguignon (Author), Sylvain Goutelle (Author), Véronique Lelong-Boulouard (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome P450 2D6 (<i>CYP2D6</i>) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for <i>CYP2D6</i> phenotyping. The objective of the CY...