Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine-hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer

• Autori principali: Mona M. Abdel-Atty (Autore), Nahla A. Farag (Autore), Rabah A. T. Serya (Autore), Khaled A. M. Abouzid (Autore), Samar Mowafy (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

A series of thieno[2,3-d]pyrimidine-based hydroxamic acid hybrids was designed and synthesised as multitarget anti-cancer agents, through incorporating the pharmacophore of EGFR, VEGFR2 into the inhibitory functionality of HDAC6. Three compounds (12c, 15b and 20b) were promising hits, whereas (12c)...