Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine-hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer

• Main Authors: Mona M. Abdel-Atty (Author), Nahla A. Farag (Author), Rabah A. T. Serya (Author), Khaled A. M. Abouzid (Author), Samar Mowafy (Author)
• Format: Bog
• Udgivet: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Fag: article
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A series of thieno[2,3-d]pyrimidine-based hydroxamic acid hybrids was designed and synthesised as multitarget anti-cancer agents, through incorporating the pharmacophore of EGFR, VEGFR2 into the inhibitory functionality of HDAC6. Three compounds (12c, 15b and 20b) were promising hits, whereas (12c)...