Synthesis of New Thiazole-Privileged Chalcones as Tubulin Polymerization Inhibitors with Potential Anticancer Activities

• Auteurs principaux: Hamada Hashem (Auteur), Abdelfattah Hassan (Auteur), Walid M. Abdelmagid (Auteur), Ahmed G. K. Habib (Auteur), Mohamed A. A. Abdel-Aal (Auteur), Ali M. Elshamsy (Auteur), Amr El Zawily (Auteur), Ibrahim Taha Radwan (Auteur), Stefan Bräse (Auteur), Ahmed S. Abdel-Samea (Auteur), Safwat M. Rabea (Auteur)
• Format: Livre
• Publié: MDPI AG, 2024-08-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

A series of novel thiazole-based chalcones were evaluated for their anticancer activity as potential tubulin polymerization inhibitors. In vitro anticancer screening for the thiazole derivatives <b>2a</b>-<b>2p</b> exhibited broad-spectrum antitumor activity against various c...