PKC-Mediated Potentiation of Morphine Analgesia by St. John's Wort in Rodents and Humans

• Main Authors: Nicoletta Galeotti (Author), Mersedeh Farzad (Author), Enrica Bianchi (Author), Carla Ghelardini (Author)
• Format: Knjiga
• Izdano: Elsevier, 2014-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Our purpose was to combine the use of morphine with clinically available inhibitors of protein kinase C (PKC), finally potentiating morphine analgesia in humans. Thermal tests were performed in rodents and humans previously administered with acute or chronic morphine combined or not with increasing...