Inhibition studies of bacterial α-carbonic anhydrases with phenols

• Hauptverfasser: Simone Giovannuzzi (Verfasst von), Chad S. Hewitt (Verfasst von), Alessio Nocentini (Verfasst von), Clemente Capasso (Verfasst von), Gabriele Costantino (Verfasst von), Daniel P. Flaherty (Verfasst von), Claudiu T. Supuran (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

The α-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogens Neisseria gonorrhoeae (NgCAα) and Vibrio cholerae (VchCAα) were investigated for their inhibition by a panel of phenols and phenolic acids. Mono-, di- and tri-substituted phenols incorporating additional hydroxyl/hydroxym...