Inhibition studies of bacterial α-carbonic anhydrases with phenols

• Egile Nagusiak: Simone Giovannuzzi (Egilea), Chad S. Hewitt (Egilea), Alessio Nocentini (Egilea), Clemente Capasso (Egilea), Gabriele Costantino (Egilea), Daniel P. Flaherty (Egilea), Claudiu T. Supuran (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The α-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogens Neisseria gonorrhoeae (NgCAα) and Vibrio cholerae (VchCAα) were investigated for their inhibition by a panel of phenols and phenolic acids. Mono-, di- and tri-substituted phenols incorporating additional hydroxyl/hydroxym...