Novel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer

• Main Authors: Chia-En Chang (Author), Chien-Ming Hsieh (Author), Ling-Chun Chen (Author), Chia-Yu Su (Author), Der-Zen Liu (Author), Hua-Jing Jhan (Author), Hsiu-O Ho (Author), Ming-Thau Sheu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synergistic combination of docetaxel (DTX) and cisplatin (CIS) by local drug delivery with a pluronic lecithin organogel (PLO) to facilitate high drug concentrations at tumor sites and less nonspecific distribution to normal organs is thought to be beneficial in chemotherapy. In this study, usin...