Genome-wide classification of epigenetic activity reveals regions of enriched heritability in immune-related traits

• Prif Awduron: Miriam Stricker (Awdur), Weijiao Zhang (Awdur), Wei-Yi Cheng (Awdur), Steven Gazal (Awdur), Calliope Dendrou (Awdur), Satu Nahkuri (Awdur), Pier Francesco Palamara (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2024-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Summary: Epigenetics underpins the regulation of genes known to play a key role in the adaptive and innate immune system (AIIS). We developed a method, EpiNN, that leverages epigenetic data to detect AIIS-relevant genomic regions and used it to detect 2,765 putative AIIS loci. Experimental validatio...