Genome-wide classification of epigenetic activity reveals regions of enriched heritability in immune-related traits

• Main Authors: Miriam Stricker (Author), Weijiao Zhang (Author), Wei-Yi Cheng (Author), Steven Gazal (Author), Calliope Dendrou (Author), Satu Nahkuri (Author), Pier Francesco Palamara (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Epigenetics underpins the regulation of genes known to play a key role in the adaptive and innate immune system (AIIS). We developed a method, EpiNN, that leverages epigenetic data to detect AIIS-relevant genomic regions and used it to detect 2,765 putative AIIS loci. Experimental validatio...