Transcriptional Profiling of Human Endothelial Cells Unveils PIEZO1 and Mechanosensitive Gene Regulation by Prooxidant and Inflammatory Inputs

• Main Authors: German A. Arenas (Author), Jose G. Valenzuela (Author), Estefanía Peñaloza (Author), Adolfo A. Paz (Author), Rodrigo Iturriaga (Author), Claudia G. Saez (Author), Bernardo J. Krause (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PIEZO1 is a mechanosensitive cation channel implicated in shear stress-mediated endothelial-dependent vasorelaxation. Since altered shear stress patterns induce a pro-inflammatory endothelial environment, we analyzed transcriptional profiles of human endothelial cells to determine the effect of alte...