Bilirubin inhibits neointima formation and vascular smooth muscle cell proliferation and migration

• Main Authors: Kelly J. Peyton (Author), Ahmad R. Shebib (Author), Mohammad A. Azam (Author), Xiao-ming eLiu (Author), David A. Tulis (Author), William eDurante (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bilirubin is a heme metabolite generated by the concerted action of the enzymes heme oxygenase and biliverdin reductase. Although long considered a toxic byproduct of heme catabolism, recent preclinical and clinical studies indicate the bilirubin exerts beneficial effects in the circulation. In the...