Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest

• Glavni autori: João Lobo (Autor), Ana Rita Cardoso (Autor), Vera Miranda-Gonçalves (Autor), Leendert H. J. Looijenga (Autor), Marie Lopez (Autor), Paola B. Arimondo (Autor), Rui Henrique (Autor), Carmen Jerónimo (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Less toxic treatment strategies for testicular germ cell tumor (TGCT) patients are needed, as overtreatment is a concern due to the long-term side effects of platin-based chemotherapy. Although clinical benefit from classical hypomethylating agents has to date been limited, TGCTs show an abnormal DN...