Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest

• Main Authors: João Lobo (Author), Ana Rita Cardoso (Author), Vera Miranda-Gonçalves (Author), Leendert H. J. Looijenga (Author), Marie Lopez (Author), Paola B. Arimondo (Author), Rui Henrique (Author), Carmen Jerónimo (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Less toxic treatment strategies for testicular germ cell tumor (TGCT) patients are needed, as overtreatment is a concern due to the long-term side effects of platin-based chemotherapy. Although clinical benefit from classical hypomethylating agents has to date been limited, TGCTs show an abnormal DN...