Oral Formulation Based on Irbesartan Nanocrystals Improve Drug Solubility, Absorbability, and Efficacy

• Hoofdauteurs: Noriaki Nagai (Auteur), Fumihiko Ogata (Auteur), Ayari Ike (Auteur), Yurisa Shimomae (Auteur), Hanano Osako (Auteur), Yosuke Nakazawa (Auteur), Naoki Yamamoto (Auteur), Naohito Kawasaki (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

We previously reported that the bioavailability (BA) of irbesartan (IRB), a BSC class II drug, was improved by preparing nanocrystalline suspensions. However, nanocrystalline suspensions have chemical and physical instabilities and must be converted into tablets through drying approaches in order to...