Oral Formulation Based on Irbesartan Nanocrystals Improve Drug Solubility, Absorbability, and Efficacy

• Main Authors: Noriaki Nagai (Author), Fumihiko Ogata (Author), Ayari Ike (Author), Yurisa Shimomae (Author), Hanano Osako (Author), Yosuke Nakazawa (Author), Naoki Yamamoto (Author), Naohito Kawasaki (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously reported that the bioavailability (BA) of irbesartan (IRB), a BSC class II drug, was improved by preparing nanocrystalline suspensions. However, nanocrystalline suspensions have chemical and physical instabilities and must be converted into tablets through drying approaches in order to...