A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline

• Main Authors: Romain Pelletier (Author), Thomas Gicquel (Author), Mélanie Simoes Eugenio (Author), Pierre-Jean Ferron (Author), Isabelle Morel (Author), Claire Delehouzé (Author), Marie-Thérèse Di (Author), Morgane Rousselot (Author), Brendan Le Daré (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sibiriline is a novel drug inhibiting receptor-interacting protein 1 kinase (RIPK1) and necroptosis, a regulated form of cell death involved in several disease models. In this study, we aimed to investigate the metabolic fate of sibiriline in a cross-sectional manner using an in silico prediction, c...