A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline

• Główni autorzy: Romain Pelletier (Autor), Thomas Gicquel (Autor), Mélanie Simoes Eugenio (Autor), Pierre-Jean Ferron (Autor), Isabelle Morel (Autor), Claire Delehouzé (Autor), Marie-Thérèse Di (Autor), Morgane Rousselot (Autor), Brendan Le Daré (Autor)
• Format: Książka
• Wydane: MDPI AG, 2022-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Sibiriline is a novel drug inhibiting receptor-interacting protein 1 kinase (RIPK1) and necroptosis, a regulated form of cell death involved in several disease models. In this study, we aimed to investigate the metabolic fate of sibiriline in a cross-sectional manner using an in silico prediction, c...