A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline

• Hoofdauteurs: Romain Pelletier (Auteur), Thomas Gicquel (Auteur), Mélanie Simoes Eugenio (Auteur), Pierre-Jean Ferron (Auteur), Isabelle Morel (Auteur), Claire Delehouzé (Auteur), Marie-Thérèse Di (Auteur), Morgane Rousselot (Auteur), Brendan Le Daré (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Sibiriline is a novel drug inhibiting receptor-interacting protein 1 kinase (RIPK1) and necroptosis, a regulated form of cell death involved in several disease models. In this study, we aimed to investigate the metabolic fate of sibiriline in a cross-sectional manner using an in silico prediction, c...