New lathyrane diterpenoid hybrids have anti-inflammatory activity through the NF-κB signaling pathway and autophagy

• Main Authors: Wang Wang (Author), Liangliang Xiong (Author), Yanli Wu (Author), Yirong Zhou (Author), Yutong Li (Author), Mengzhu Zheng (Author), Zhuorui Song (Author), Dejuan Sun (Author), Lixia Chen (Author)
• Format: Book
• Published: Compuscript Ltd, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In our ongoing work on the identification of potent anti-inflammatory agents, we designed and synthesized three series of lathyrane diterpenoid hybrids in which the lathyrane diterpenoid skeleton was hybridized with other anti-inflammatory pharmacophores. Unexpectedly, lathyrane diterpenoid/3-hydrox...