β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes

• Egile Nagusiak: Shin-ichi Oka (Egilea), Fan Tang (Egilea), Adave Chin (Egilea), Guersom Ralda (Egilea), Xiaoyong Xu (Egilea), Chengchen Hu (Egilea), Zhi Yang (Egilea), Maha Abdellatif (Egilea), Junichi Sadoshima (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Thioredoxin 1 (Trx1) is a major antioxidant that acts adaptively to protect the heart during the development of diabetic cardiomyopathy. The molecular mechanism(s) responsible for regulating the Trx1 level and/or activity during diabetic cardiomyopathy is unknown. β-hydroxybutyrate (βHB), a major ke...