β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes

• Main Authors: Shin-ichi Oka (Author), Fan Tang (Author), Adave Chin (Author), Guersom Ralda (Author), Xiaoyong Xu (Author), Chengchen Hu (Author), Zhi Yang (Author), Maha Abdellatif (Author), Junichi Sadoshima (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thioredoxin 1 (Trx1) is a major antioxidant that acts adaptively to protect the heart during the development of diabetic cardiomyopathy. The molecular mechanism(s) responsible for regulating the Trx1 level and/or activity during diabetic cardiomyopathy is unknown. β-hydroxybutyrate (βHB), a major ke...