Rapid identification and isolation of neuraminidase inhibitors from mockstrawberry (Duchesnea indica Andr.) based on ligand fishing combined with HR-ESI-Q-TOF-MS

• Egile Nagusiak: Sifan Luo (Egilea), Linbo Guo (Egilea), Caimin Sheng (Egilea), Yumei Zhao (Egilea), Ling Chen (Egilea), Chufang Li (Egilea), Zhengjin Jiang (Egilea), Haiyan Tian (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2020-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Neuraminidase inhibitors (NAIs) are the mainstay antiviral drugs against influenza infection. In this study, a ligand fishing protocol was developed to screen NAIs using neuraminidase immobilized magnetic beads (NA-MB). After verifying the feasibility of NA-MB with an artificial mixture including NA...