Teriflunomide preserves peripheral nerve mitochondria from oxidative stress-mediated alterations

• Main Authors: Bimala Malla (Author), Samuel Cotten (Author), Rebecca Ulshoefer (Author), Friedemann Paul (Author), Anja E. Hauser (Author), Raluca Niesner (Author), Helena Bros (Author), Carmen Infante-Duarte (Author)
• Format: Book
• Published: SAGE Publishing, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial dysfunction is a common pathological hallmark in various inflammatory and degenerative diseases of the central nervous system, including multiple sclerosis (MS). We previously showed that oxidative stress alters axonal mitochondria, limiting their transport and inducing conformational...