Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated

• Главные авторы: Sara Polo (Автор), Andrés Felipe Díaz (Автор), Núria Gallardo (Автор), Sergi Leánez (Автор), Gianfranco Balboni (Автор), Olga Pol (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Предметы: article
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We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associat...