Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated

• Autori principali: Sara Polo (Autore), Andrés Felipe Díaz (Autore), Núria Gallardo (Autore), Sergi Leánez (Autore), Gianfranco Balboni (Autore), Olga Pol (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associat...