Inhibitory monoclonal antibodies against mouse proteases raised in gene-deficient mice block proteolytic functions in vivo

• मुख्य लेखकों: Ida Katrine Lund (लेखक), Morten Grønbech Rasch (लेखक), Signe eIngvarsen (लेखक), Jesper ePass (लेखक), Daniel H Madsen (लेखक), Lars H Engelholm (लेखक), Niels eBehrendt (लेखक), Gunilla eHøyer-Hansen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2012-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Identification of targets for cancer therapy requires the understanding of the in vivo roles of proteins, which can be derived from studies using gene-targeted mice. An alternative strategy is the administration of inhibitory monoclonal antibodies (mAbs), causing acute disruption of the target prote...