Inhibitory monoclonal antibodies against mouse proteases raised in gene-deficient mice block proteolytic functions in vivo

• Main Authors: Ida Katrine Lund (Author), Morten Grønbech Rasch (Author), Signe eIngvarsen (Author), Jesper ePass (Author), Daniel H Madsen (Author), Lars H Engelholm (Author), Niels eBehrendt (Author), Gunilla eHøyer-Hansen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Identification of targets for cancer therapy requires the understanding of the in vivo roles of proteins, which can be derived from studies using gene-targeted mice. An alternative strategy is the administration of inhibitory monoclonal antibodies (mAbs), causing acute disruption of the target prote...